Genomics

Dataset Information

3

Chlamydia abortus vaccine clade


ABSTRACT: The genome sequence of Chlamydia abortus strain AB7

ORGANISM(S): Chlamydia abortus  

PROVIDER: PRJEB6919 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
GCA_000952935.1_sequence_report.txt Txt
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Publications

Genomic evidence that the live Chlamydia abortus vaccine strain 1B is not attenuated and has the potential to cause disease.

Longbottom David D   Sait Michelle M   Livingstone Morag M   Laroucau Karine K   Sachse Konrad K   Harris Simon R SR   Thomson Nicholas R NR   Seth-Smith Helena M B HMB  

Vaccine 20180601 25


<h4>Background</h4>The live, temperature-attenuated vaccine strain 1B of Chlamydia abortus, the aetiological agent of ovine enzootic abortion (OEA), has been implicated in cases of vaccine breakdown. The aim of this study was to understand the nature of this attenuation through sequencing of the vaccine parent strain (AB7) and the derived mutant strains 1B and 1H, as well as to clarify the role of the vaccine strain in causing disease through comparative whole genome analysis.<h4>Methods</h4>Who  ...[more]

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