Genomics

Dataset Information

315

Massive, unselected amplification of the CUP locus associated with chromosomal rearrangements in severely unfit haploid S. cerevisiae cells.


ABSTRACT: Description

PROVIDER: PRJEB8937 | ENA |

REPOSITORIES: ENA

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Publications

Massive Amplification at an Unselected Locus Accompanies Complex Chromosomal Rearrangements in Yeast.

Thierry Agnès A   Khanna Varun V   Dujon Bernard B  

G3 (Bethesda, Md.) 20160503 5


Gene amplification has been observed in different organisms in response to environmental constraints, such as limited nutrients or exposure to a variety of toxic compounds, conferring them with specific phenotypic adaptations via increased expression levels. However, the presence of multiple gene copies in natural genomes has generally not been found in the absence of specific functional selection. Here, we show that the massive amplification of a chromosomal locus (up to 880 copies per cell) oc  ...[more]

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