Genomics,Multiomics

Dataset Information

0

Mus musculus


ABSTRACT: Murine ES cells, neural precursor cells and embryonic fibroblasts

OTHER RELATED OMICS DATASETS IN: E-GEOD-8024E-GEOD-12241

PROVIDER: PRJNA100829 | ENA |

REPOSITORIES: ENA

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Publications


We report the application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells. By obtaining over four billion bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide chromatin-state maps of mouse embryonic stem cells, neural progenitor cells and embryonic fibroblasts. We find that lysine 4 and lysine 27 trimethylation effectively discriminates genes that are expressed, poised for expression, or stably  ...[more]

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