ABSTRACT: Gene expression profiles of E15.5 cortical collecting duct and anlage of loop of Henle isolated from developing kidney using LCM. (GUDMAP Series ID: 18)
Project description:We profiled SUMO1 and SUMO2 modified proteins in cortical collecting duct (mpkCCD) as a precursor to targeted approaches to assess SUMO function. SUMO levels in cells following heat shock and treatment with deSUMOylation inhibitors were assessed.
Project description:To study the effects of aldosterone on miRNA in the kidney cortical collecting duct, polarized mpkCCDc14 cell were treated with aldosterone or vehicle. A putative target for miR-466g was identified, the effect of modulating miR-466g levels on SGK1 levels was examined
Project description:This experiment aimed to uncover the genome-wide alternation in gene expression resulting from the removal of PRR from the population ureteric bud and collecting duct and successive changes to the series of events in kidney development.
