Genomics

Dataset Information

59

RNA binding activity of the recessive parkinsonism protein DJ-1


ABSTRACT: RNA binding activity of the recessive parkinsonism protein DJ-1

PROVIDER: PRJNA101815 | ENA |

REPOSITORIES: ENA

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RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways.

van der Brug Marcel P MP   Blackinton Jeff J   Chandran Jayanth J   Hao Ling-Yang LY   Lal Ashish A   Mazan-Mamczarz Krystyna K   Martindale Jennifer J   Xie Chengsong C   Ahmad Rili R   Thomas Kelly J KJ   Beilina Alexandra A   Gibbs J Raphael JR   Ding Jinhui J   Myers Amanda J AJ   Zhan Ming M   Cai Huaibin H   Bonini Nancy M NM   Gorospe Myriam M   Cookson Mark R MR  

Proceedings of the National Academy of Sciences of the United States of America 20080714 29


Parkinson's disease (PD) is a major neurodegenerative condition with several rare Mendelian forms. Oxidative stress and mitochondrial function have been implicated in the pathogenesis of PD but the molecular mechanisms involved in the degeneration of neurons remain unclear. DJ-1 mutations are one cause of recessive parkinsonism, but this gene is also reported to be involved in cancer by promoting Ras signaling and suppressing PTEN-induced apoptosis. The specific function of DJ-1 is unknown, alth  ...[more]

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