Dataset Information


Homo sapiens

ABSTRACT: Intestinal xenotransplants infected with Shigella

ORGANISM(S): Homo sapiens  



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Virulent Shigella flexneri subverts the host innate immune response through manipulation of antimicrobial peptide gene expression.

Sperandio Brice B   Regnault Béatrice B   Guo Jianhua J   Zhang Zhi Z   Stanley Samuel L SL   Sansonetti Philippe J PJ   Pédron Thierry T  

The Journal of experimental medicine 20080421 5

Antimicrobial factors are efficient defense components of the innate immunity, playing a crucial role in the intestinal homeostasis and protection against pathogens. In this study, we report that upon infection of polarized human intestinal cells in vitro, virulent Shigella flexneri suppress transcription of several genes encoding antimicrobial cationic peptides, particularly the human beta-defensin hBD-3, which we show to be especially active against S. flexneri. This is an example of targeted  ...[more]

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