Dataset Information


Mycobacterium tuberculosis

ABSTRACT: Regulation of the Mycobacterium tuberculosishypoxic response gene encoding alpha-crystallin

ORGANISM(S): Mycobacterium tuberculosis  



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Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha -crystallin.

Sherman D R DR   Voskuil M M   Schnappinger D D   Liao R R   Harrell M I MI   Schoolnik G K GK  

Proceedings of the National Academy of Sciences of the United States of America 20010601 13

Unlike many pathogens that are overtly toxic to their hosts, the primary virulence determinant of Mycobacterium tuberculosis appears to be its ability to persist for years or decades within humans in a clinically latent state. Since early in the 20th century latency has been linked to hypoxic conditions within the host, but the response of M. tuberculosis to a hypoxic signal remains poorly characterized. The M. tuberculosis alpha-crystallin (acr) gene is powerfully and rapidly induced at reduced  ...[more]

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