Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: TFAP2C regulates multiple pathways of estrogen signaling

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA101825 | ENA |

REPOSITORIES: ENA

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Publications

TFAP2C controls hormone response in breast cancer cells through multiple pathways of estrogen signaling.

Woodfield George W GW   Horan Annamarie D AD   Chen Yizhen Y   Weigel Ronald J RJ  

Cancer research 20070901 18


Breast cancers expressing estrogen receptor-alpha (ERalpha) are associated with a favorable biology and are more likely to respond to hormonal therapy. In addition to ERalpha, other pathways of estrogen response have been identified including ERbeta and GPR30, a membrane receptor for estrogen, and the key mechanisms regulating expression of ERs and hormone response remain controversial. Herein, we show that TFAP2C is the key regulator of hormone responsiveness in breast carcinoma cells through t  ...[more]

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