Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Rnf41 is associated with anxiety like behavior, major depression and beta carboline induced seizure

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA101827 | ENA |

REPOSITORIES: ENA

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Publications

An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger 41, is a candidate gene for anxiety-like behavior and beta-carboline-induced seizures.

Kim Sanghyeon S   Zhang Shumin S   Choi Kwang H KH   Reister Robin R   Do Chi C   Baykiz Ali F AF   Gershenfeld Howard K HK  

Biological psychiatry 20081104 5


Identification of the genes underlying psychiatric illness remains a thorny problem. Previously, Quantitative Trait Loci (QTL) for anxiety-like behaviors and beta-carboline-induced seizure vulnerability have been mapped to the distal portion of mouse chromosome 10, with crosses of A/J and C57BL6 mice.An interval specific congenic strain for this chromosomal 10 region facilitated the genetic dissection of novelty-induced exploratory behaviors.By microarray studies, an unsuspected E3 ubiquitin lig  ...[more]

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