Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Molecular mechanisms of liver carcinogenesis in the Mdr2-knockout mice

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA101829 | ENA |

REPOSITORIES: ENA

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Publications


Mouse models of hepatocellular carcinoma (HCC) simulate specific subgroups of human HCC. We investigated hepatocarcinogenesis in Mdr2-knockout (Mdr2-KO) mice, a model of inflammation-associated HCC, using gene expression profiling and immunohistochemical analyses. Gene expression profiling showed that although Mdr2-KO mice differ from other published murine HCC models, they share several important deregulated pathways and many coordinately differentially expressed genes with human HCC data sets.  ...[more]

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