Dataset Information


Homo sapiens

ABSTRACT: Human hepatocellular carcinomas validation set

ORGANISM(S): Homo sapiens  



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Decoding global gene expression programs in liver cancer by noninvasive imaging.

Segal Eran E   Sirlin Claude B CB   Ooi Clara C   Adler Adam S AS   Gollub Jeremy J   Chen Xin X   Chan Bryan K BK   Matcuk George R GR   Barry Christopher T CT   Chang Howard Y HY   Kuo Michael D MD  

Nature biotechnology 20070521 6

Paralleling the diversity of genetic and protein activities, pathologic human tissues also exhibit diverse radiographic features. Here we show that dynamic imaging traits in non-invasive computed tomography (CT) systematically correlate with the global gene expression programs of primary human liver cancer. Combinations of twenty-eight imaging traits can reconstruct 78% of the global gene expression profiles, revealing cell proliferation, liver synthetic function, and patient prognosis. Thus, ge  ...[more]

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