Dataset Information


Mus musculus

ABSTRACT: CLL in Em-TCL1 mice provides a biologically relevant model to unravel and reverse immune deficiency in human cancer.

ORGANISM(S): Mus musculus  



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E(mu)-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction.

Gorgun Gullu G   Ramsay Alan G AG   Holderried Tobias A W TA   Zahrieh David D   Le Dieu Rifca R   Liu Fenglong F   Quackenbush John J   Croce Carlo M CM   Gribben John G JG  

Proceedings of the National Academy of Sciences of the United States of America 20090330 15

Preclinical animal models have largely ignored the immune-suppressive mechanisms that are important in human cancers. The identification and use of such models should allow better predictions of successful human responses to immunotherapy. As a model for changes induced in nonmalignant cells by cancer, we examined T-cell function in the chronic lymphocytic leukemia (CLL) Emu-TCL1 transgenic mouse model. With development of leukemia, Emu-TCL1 transgenic mice developed functional T-cell defects an  ...[more]

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