Dataset Information


Rattus norvegicus

ABSTRACT: Circadian regulation in rat skeletal muscle

ORGANISM(S): Rattus norvegicus  



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Relationships between circadian rhythms and modulation of gene expression by glucocorticoids in skeletal muscle.

Almon Richard R RR   Yang Eric E   Lai William W   Androulakis Ioannis P IP   Ghimbovschi Svetlana S   Hoffman Eric P EP   Jusko William J WJ   Dubois Debra C DC  

American journal of physiology. Regulatory, integrative and comparative physiology 20080730 4

The existence and maintenance of biological rhythms linked to the 24-h light-dark cycle are essential to the health and functioning of an organism. Although much is known concerning central clock mechanisms, much less is known about control in peripheral tissues. In this study, circadian regulation of gene expression was examined in rat skeletal muscle. A rich time series involving 54 animals euthanized at 18 distinct time points within the 24-h cycle was performed, and mRNA expression in gastro  ...[more]

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