Homo sapiens
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA102533 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Human myeloma cell lines gene expression profiling
| PRJNA100619 | ENA
Project description:Expression data from cell lines originating from patients with multiple myeloma, plasmacytoma and diffuse large B-cell lymphoma
| PRJNA128271 | ENA
Project description:Comparison of the gene expression profiles of carfilzomib-resistant derivatives versus parental human myeloma cell lines
| PRJNA284490 | ENA
Project description: Not available
| S-EPMC2531291 | biostudies-literature
Project description:RNA extracted at 240min. Samples are rRNA depleted. Expression measurement of Homo sapiens genes.
2019-07-31 | GSE114179 | GEO
Project description:Microarray screening of RNA samples from two human myeloma and two human lymphoma cell lines
| PRJNA138273 | ENA
Project description:Analysis of human myeloma cell lines expressing beta 3 integrin
| PRJNA116971 | ENA
Project description:Gene expression from H69M versus H69 SCLC cell lines
| PRJNA193082 | ENA
Project description:Background Epigenetic changes are involved in the extinction of the B-cell gene expression program of classical Hodgkin lymphoma. However, little is known regarding epigenetic similarities between classical Hodgkin lymphoma and plasma cell myeloma cells, both of which share an extinction of the gene expression program of mature B-cells. Design and methods Global histone H3 acetylation patterns were determined in cell lines derived from classical Hodgkin lymphoma, plasma cell myeloma and B-cell lymphoma by chromatin immunoprecipitation and subsequent hybridization onto promoter tiling arrays. H3K27 trimethylation was analyzed by chromatin immunoprecipitation and real-time DNA-PCR for selected genes. Epigenetic modifications were compared to gene expression data. Results B-cell characteristic genes were hypoacetylated in classical Hodgkin lymphoma and plasma cell myeloma cell lines, as demonstrated by comparison of their histone H3 acetylation patterns to those of B-cell lines. However, the number of genes jointly hyperacetylated and expressed in classical Hodgkin lymphoma and plasma cell myeloma cell lines, such as IFR4/MUM1 and RYBP, is limited. Moreover, H3K27 trimethylation for selected B-cell characteristic genes revealed that this additional epigenetic silencing is much more prevalent in classical Hodgkin lymphoma as compared to plasma cell myeloma. Conclusion Our epigenetic data support the view that classical Hodgkin lymphoma is characterized by an abortive plasma cell differentiation with a down-regulation of B-cell characteristic genes but without activation of most plasma cell typical genes.
2011-05-05 | GSE21252 | GEO