Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Prostaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA103823 | ENA |

REPOSITORIES: ENA

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Publications

Prostaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4.

Murn Jernej J   Alibert Olivier O   Wu Ning N   Tendil Simon S   Gidrol Xavier X  

The Journal of experimental medicine 20081215 13


B cell receptor (BCR) signaling contributes to the pathogenesis of B cell malignancies, and most B cell lymphomas depend on BCR signals for survival. Identification of genes that restrain BCR-mediated proliferation is therefore an important goal toward improving the therapy of B cell lymphoma. Here, we identify Ptger4 as a negative feedback regulator of proliferation in response to BCR signals and show that its encoded EP4 receptor is a principal molecule conveying the growth-suppressive effect  ...[more]

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