Dataset Information


Streptococcus pneumoniae

ABSTRACT: Wild type vs glnPA double mutant

ORGANISM(S): Streptococcus pneumoniae  



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Site-specific contributions of glutamine-dependent regulator GlnR and GlnR-regulated genes to virulence of Streptococcus pneumoniae.

Hendriksen Wouter T WT   Kloosterman Tomas G TG   Bootsma Hester J HJ   Estevão Silvia S   de Groot Ronald R   Kuipers Oscar P OP   Hermans Peter W M PW  

Infection and immunity 20080103 3

The transcriptional regulator GlnR of Streptococcus pneumoniae is involved in the regulation of glutamine and glutamate metabolism, controlling the expression of the glnRA and glnPQ-zwf operons, as well as the gdhA gene. To assess the contribution of the GlnR regulon to virulence, D39 wild-type and mutant strains lacking genes of this regulon were tested in an in vitro adherence assay and murine infection models. All of the mutants, except the DeltaglnR mutant, were attenuated in adherence to hu  ...[more]

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