Genomics

Dataset Information

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ABSTRACT: Striatal gene expression data from 12 weeks-old R6/2 mice and control mice

PROVIDER: PRJNA103837 | ENA |

REPOSITORIES: ENA

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Publications


To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD) and postmortem human HD caudate. Transgenic models expressing short N-terminal fragments of mutant huntingtin (R6/1 and R6/2 mice) exhibited the most rapid effects on gene expression, consistent with previous studies. Although changes in the bra  ...[more]

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