Dataset Information


Plasmodium falciparum

ABSTRACT: Hard-wiring in the Plasmodium falciparum transcriptome II

ORGANISM(S): Plasmodium falciparum  



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A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates.

Ganesan Karthikeyan K   Ponmee Napawan N   Jiang Lei L   Fowble Joseph W JW   White John J   Kamchonwongpaisan Sumalee S   Yuthavong Yongyuth Y   Wilairat Prapon P   Rathod Pradipsinh K PK  

PLoS pathogens 20081121 11

Genome sequences of Plasmodium falciparum allow for global analysis of drug responses to antimalarial agents. It was of interest to learn how DNA microarrays may be used to study drug action in malaria parasites. In one large, tightly controlled study involving 123 microarray hybridizations between cDNA from isogenic drug-sensitive and drug-resistant parasites, a lethal antifolate (WR99210) failed to over-produce RNA for the genetically proven principal target, dihydrofolate reductase-thymidylat  ...[more]

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