Dataset Information


Homo sapiens

ABSTRACT: Expression data from human liver cell line induced by PCB77

ORGANISM(S): Homo sapiens  



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PCB congener specific oxidative stress response by microarray analysis using human liver cell line.

De Supriyo S   Ghosh Somiranjan S   Chatterjee Raghunath R   Chen Y-Q YQ   Moses Linda L   Kesari Akanchha A   Hoffman Eric P EP   Dutta Sisir K SK  

Environment international 20100717 8

In this study we have examined the effect of exposure to different congeners of PCBs and their role in oxidative stress response. A metabolically competent human liver cell line (HepG2) was exposed with two prototype congeners of PCBs: coplanar PCB-77 and non-coplanar PCB-153. After the predetermined times of exposure (0-24h) at 70 μM concentration, the HepG2 cells showed significant apoptotic changes by fluorescent microscopy after 12h of exposure. Gene set enrichment analysis (GSEA) identified  ...[more]

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