Project description:This SuperSeries is composed of the following subset Series:; GSE357: Halothane Repetitive Exposure; GSE358: Isoflurane Repetitive Exposure; GSE752: Halothane/Isoflurane Repetitive Exposures Experiment Overall Design: Refer to individual Series
Project description:d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. Affymetrix microarray technology was used to determine differential gene expression resulting from D-Serine exposure. Keywords: Dose course
