Dataset Information


Homo sapiens

ABSTRACT: ALL Translocations

ORGANISM(S): Homo sapiens  



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Gene expression patterns associated with recurrent chromosomal translocations in acute lymphoblastic leukemia.

Fine Bernard M BM   Stanulla Martin M   Schrappe Martin M   Ho Minh M   Viehmann Susanne S   Harbott Jochen J   Boxer Linda M LM  

Blood 20031002 3

We obtained a global view of gene expression in both cell lines and pediatric acute lymphoblastic leukemia (ALL) samples that harbor one of several selected chromosomal abnormalities. When the cell lines were studied alone, we found that these chromosomal abnormalities were associated with the predominant variation in transcriptional programs across the set of cell lines studied. When cell lines and clinical samples were studied together, we found that each chromosomal abnormality (TEL/AML1, BCR  ...[more]

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