Dataset Information


Homo sapiens

ABSTRACT: Human Pancreas tumor vs Normal Human DNA

ORGANISM(S): Homo sapiens  



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Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.

Maser Richard S RS   Choudhury Bhudipa B   Campbell Peter J PJ   Feng Bin B   Wong Kwok-Kin KK   Protopopov Alexei A   O'Neil Jennifer J   Gutierrez Alejandro A   Ivanova Elena E   Perna Ilana I   Lin Eric E   Mani Vidya V   Jiang Shan S   McNamara Kate K   Zaghlul Sara S   Edkins Sarah S   Stevens Claire C   Brennan Cameron C   Martin Eric S ES   Wiedemeyer Ruprecht R   Kabbarah Omar O   Nogueira Cristina C   Histen Gavin G   Aster Jon J   Mansour Marc M   Duke Veronique V   Foroni Letizia L   Fielding Adele K AK   Goldstone Anthony H AH   Rowe Jacob M JM   Wang Yaoqi A YA   Look A Thomas AT   Stratton Michael R MR   Chin Lynda L   Futreal P Andrew PA   DePinho Ronald A RA  

Nature 20070521 7147

Highly rearranged and mutated cancer genomes present major challenges in the identification of pathogenetic events driving the neoplastic transformation process. Here we engineered lymphoma-prone mice with chromosomal instability to assess the usefulness of mouse models in cancer gene discovery and the extent of cross-species overlap in cancer-associated copy number aberrations. Along with targeted re-sequencing, our comparative oncogenomic studies identified FBXW7 and PTEN to be commonly delete  ...[more]

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