Genomics

Dataset Information

0

Mus musculus


ABSTRACT: T cell-expressed proprotein convertase furin is essential for maintenance of peripheral tolerance

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA105703 | ENA |

REPOSITORIES: ENA

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Publications


Furin is one of seven proprotein convertase family members that promote proteolytic maturation of proproteins. It is induced in activated T cells and is reported to process a variety of substrates including the anti-inflammatory cytokine transforming growth factor (TGF)-beta1 (refs 2-4), but the non-redundant functions of furin versus other proprotein convertases in T cells are unclear. Here we show that conditional deletion of furin in T cells allowed for normal T-cell development but impaired  ...[more]

Publication: 1/2

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