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Mus musculus

ABSTRACT: Virus-Induced Airway Disease in Mice (C57BL/6J, d21/d49)

OTHER RELATED OMICS DATASETS IN: E-GEOD-10964

PROVIDER: PRJNA107165 | ENA |

REPOSITORIES: ENA

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Mus musculus

Project description:Virus-Induced Airway Disease in Mice (C57BL/6J, d3)

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Mus musculus

Project description:Virus-Induced Airway Disease in Mice (C57BL/6J, d49)

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Virus-Induced Airway Disease in Mice (C57BL/6J, d49)

Project description:Analysis of gene expression in lungs of C57BL/6J mice that develop chronic airway disease phenotypes after a single Sendai virus infection, compared with mice treated with UV-inactivated virus. Keywords: disease state analysis Whole lung RNA was analyzed from 3 mice per condition per time point 49 days post infection, Sendai virus versus UV-inactivated virus, C57BL/6J mouse strain.

2013-08-08 | E-GEOD-49603 | biostudies-arrayexpress

Virus-Induced Airway Disease in Mice (C57BL/6J, d3)

Project description:Analysis of gene expression in lungs of C57BL/6J mice that develop chronic airway disease phenotypes after a single Sendai virus infection, compared with mice treated with UV-inactivated virus. Keywords: disease state analysis Whole lung RNA was analyzed from 3 mice per condition per time point 3 days post infection, Sendai virus versus UV-inactivated virus, C57BL/6J mouse strain.

2015-03-27 | E-GEOD-61437 | biostudies-arrayexpress

Virus-Induced Airway Disease in Mice (C57BL/6J, d21/d49)

2008-05-17 | GSE10964 | GEO

Virus-Induced Airway Disease in Mice (C57BL/6J, d49)

2013-08-08 | GSE49603 | GEO

Virus-Induced Airway Disease in Mice (C57BL/6J, d3)

2015-03-27 | GSE61437 | GEO

Virus-Induced Airway Disease in Mice (C57BL/6J, d21/d49)

2008-05-17 | GSE10964 | GEO

Transcription profiling of mouse C57BL/6J strain infected with Sendai virus vs. UV irradiated virus to investigate virus-induced airway disease

Project description:Analysis of gene expression in lungs of C57BL/6J mice that develop chronic airway disease phenotypes after a single Sendai virus infection, compared with mice treated with UV-inactivated virus. Experiment Overall Design: Whole lung RNA was analyzed from 3 mice per condition per time point for days 21 and 49 post infection, Sendai virus versus UV-inactivated virus, C57BL/6J mouse strain.

2008-06-20 | E-GEOD-10964 | biostudies-arrayexpress

Mapping of a QTL for airway hyperresponsiveness on mouse chromosome 12

Project description:The BcA86 strain is a unique recombinant congenic strain created from parental strains A/J and C57BL/6J. Naive mice from the BcA86 strain have a lung responsiveness phenotype resembling mice from airway hyperresponsive strain A/J. However, majority of the BcA86 genome is from the hyporesponsive strain C57BL/6J. Our goal was to identify the genomic regions that are associated with this BcA86 phenotype. Using F2 mice generated from BcA86 backcrossed to C57BL/6J, we identified a QTL for airway hyperresponsiveness on mouse chromosome 12. We validated the importance of mouse chromosome 12 in airway responsiveness using a chromosome 12 substitution strain (CSS12) which contains A/J chromosome 12 on a C57BL/6J background. The CSS12 strain also had a lung responsiveness phenotype similar to A/J. We selected genes within our QTL as candidates for airway hyperresponsiveness if they contained a deleterious coding variant (based on PROVEAN analysis) or if they were differently expressed between hyperresponsive (A/J, BcA86, CSS12) and hyporesponsive (C57BL/6J) strains.

2014-11-11 | GSE52356 | GEO

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