Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Comparison of the transcriptional profiles of the retinal pigmental epithelium/choroid from young and old mice

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA107167 | ENA |

REPOSITORIES: ENA

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Publications

The aged retinal pigment epithelium/choroid: a potential substratum for the pathogenesis of age-related macular degeneration.

Chen Huiyi H   Liu Bin B   Lukas Thomas J TJ   Neufeld Arthur H AH  

PloS one 20080604 6


<h4>Background</h4>Although the statement that age is the greatest risk factor for Age-related macular degeneration (AMD) is widely accepted, the cellular and molecular explanations for that clinical statement are not generally known. A major focus of AMD research is the retinal pigment epithelium (RPE)/choroid. The purpose of this study was to characterize the changes in the RPE/choroid with age that may provide a background for the development of AMD.<h4>Methodology/principal findings</h4>We c  ...[more]

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