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ABSTRACT: Non-small Cell Lung Cancer (qRT-PCR)



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Global gene expression analysis reveals specific patterns of cell junctions in non-small cell lung cancer subtypes.

Kuner Ruprecht R   Muley Thomas T   Meister Michael M   Ruschhaupt Markus M   Buness Andreas A   Xu Elizabeth C EC   Schnabel Phillipp P   Warth Arne A   Poustka Annemarie A   Sültmann Holger H   Hoffmann Hans H  

Lung cancer (Amsterdam, Netherlands) 20080516 1

Non-small cell lung cancer (NSCLC) can be classified into the major subtypes adenocarcinoma (AC) and squamous cell carcinoma (SCC). Although explicit molecular, histological and clinical characteristics have been reported for both subtypes, no specific therapy exists so far. However, the characterization of suitable molecular targets holds great promises to develop novel therapies in NSCLC. In the present study, global gene expression profiling of 58 human NSCLC specimens revealed large transcri  ...[more]

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