Dataset Information


Homo sapiens

ABSTRACT: AdHBx UV vs AdEasy UV vs HepG2

ORGANISM(S): Homo sapiens  



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Deregulated direct targets of the hepatitis B virus (HBV) protein, HBx, identified through chromatin immunoprecipitation and expression microarray profiling.

Sung Wing-Kin WK   Lu Yiwei Y   Lee Charlie W H CWH   Zhang Dongwei D   Ronaghi Mostafa M   Lee Caroline G L CGL  

The Journal of biological chemistry 20090513 33

The hepatitis B-X (HBx) protein is strongly associated with hepatocellular carcinoma. It is implicated not to directly cause cancer but to play a role in hepatocellular carcinoma as a co-factor. The oncogenic potential of HBx primarily lies in its interaction with transcriptional regulators resulting in aberrant gene expression and deregulated cellular pathways. Utilizing ultraviolet irradiation to simulate a tumor-initiating event, we integrated chip-based chromatin immunoprecipitation (ChIP-ch  ...[more]

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