Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Myc influences embryonic stem cell pluripotency by regulating miRNAs

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA109671 | ENA |

REPOSITORIES: ENA

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Publications

Myc-regulated microRNAs attenuate embryonic stem cell differentiation.

Lin Chin-Hsing CH   Jackson Aimee L AL   Guo Jie J   Linsley Peter S PS   Eisenman Robert N RN  

The EMBO journal 20090910 20


Myc proteins are known to have an important function in stem cell maintenance. As Myc has been shown earlier to regulate microRNAs (miRNAs) involved in proliferation, we sought to determine whether c-Myc also affects embryonic stem (ES) cell maintenance and differentiation through miRNAs. Using a quantitative primer-extension PCR assay we identified miRNAs, including, miR-141, miR-200, and miR-429 whose expression is regulated by c-Myc in ES cells, but not in the differentiated and tumourigenic  ...[more]

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