Dataset Information


Mus musculus

ABSTRACT: Expression profiles of (40,XX) and (39,XO) females

ORGANISM(S): Mus musculus  



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Transcriptional changes in response to X chromosome dosage in the mouse: implications for X inactivation and the molecular basis of Turner Syndrome.

Lopes Alexandra M AM   Burgoyne Paul S PS   Ojarikre Andrew A   Bauer Julien J   Sargent Carole A CA   Amorim António A   Affara Nabeel A NA  

BMC genomics 20100201

X monosomic mice (39,XO) have a remarkably mild phenotype when compared to women with Turner syndrome (45,XO). The generally accepted hypothesis to explain this discrepancy is that the number of genes on the mouse X chromosome which escape X inactivation, and thus are expressed at higher levels in females, is very small. However this hypothesis has never been tested and only a small number of genes have been assayed for their X-inactivation status in the mouse. We performed a global expression a  ...[more]

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