Genomics

Dataset Information

294


ABSTRACT: Analyses of cyclin D1 function using a "genetic-proteomic" approach

PROVIDER: PRJNA110183 | ENA |

REPOSITORIES: ENA

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Publications


Cyclin D1 belongs to the core cell cycle machinery, and it is frequently overexpressed in human cancers. The full repertoire of cyclin D1 functions in normal development and oncogenesis is unclear at present. Here we developed Flag- and haemagglutinin-tagged cyclin D1 knock-in mouse strains that allowed a high-throughput mass spectrometry approach to search for cyclin D1-binding proteins in different mouse organs. In addition to cell cycle partners, we observed several proteins involved in trans  ...[more]

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