Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Reversible and irreversible anchorage independent growth in skin cells

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA110237 | ENA |

REPOSITORIES: ENA

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Publications

Cellular dichotomy between anchorage-independent growth responses to bFGF and TPA reflects molecular switch in commitment to carcinogenesis.

Waters Katrina M KM   Tan Ruimin R   Opresko Lee K LK   Quesenberry Ryan D RD   Bandyopadhyay Somnath S   Chrisler William B WB   Weber Thomas J TJ  

Molecular carcinogenesis 20091101 11


We have investigated gene expression patterns underlying reversible and irreversible anchorage-independent growth (AIG) phenotypes to identify more sensitive markers of cell transformation for studies directed at interrogating carcinogenesis responses. In JB6 mouse epidermal cells, basic fibroblast growth factor (bFGF) induces an unusually efficient and reversible AIG response, relative to 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced AIG which is irreversible. The reversible and irreversi  ...[more]

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