Dataset Information


Homo sapiens

ABSTRACT: Response of p53 isogenic colorectal cancer panel to 12 Gy gamma irradiation

ORGANISM(S): Homo sapiens  



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A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53.

Sur Surojit S   Pagliarini Raymond R   Bunz Fred F   Rago Carlo C   Diaz Luis A LA   Kinzler Kenneth W KW   Vogelstein Bert B   Papadopoulos Nickolas N  

Proceedings of the National Academy of Sciences of the United States of America 20090218 10

Through targeted homologous recombination, we developed a panel of matched colorectal cancer cell lines that differ only with respect to their endogenous TP53 status. We then used these lines to define the genes whose expression was altered after DNA damage induced by ionizing radiation. Transcriptome analyses revealed a consistent up-regulation of polo-like kinase 1 (PLK1) as well as other genes controlling the G(2)/M transition in the cells whose TP53 genes were inactivated compared with those  ...[more]

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