Dataset Information


Mus musculus

ABSTRACT: Higher Order Chromosomal Network of Imprinted Loci

ORGANISM(S): Mus musculus  



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Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development.

Sandhu Kuljeet Singh KS   Shi Chengxi C   Sjölinder Mikael M   Zhao Zhihu Z   Göndör Anita A   Liu Liang L   Tiwari Vijay K VK   Guibert Sylvain S   Emilsson Lina L   Imreh Marta P MP   Ohlsson Rolf R  

Genes & development 20091101 22

Recent observations highlight that the mammalian genome extensively communicates with itself via long-range chromatin interactions. The causal link between such chromatin cross-talk and epigenetic states is, however, poorly understood. We identify here a network of physically juxtaposed regions from the entire genome with the common denominator of being genomically imprinted. Moreover, CTCF-binding sites within the H19 imprinting control region (ICR) not only determine the physical proximity amo  ...[more]

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