Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: MKL1 promotes megakaryocytic differentiation in HEL cells

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA110383 | ENA |

REPOSITORIES: ENA

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Publications


Megakaryoblastic leukemia 1 (MKL1), identified as part of the t(1;22) translocation specific to acute megakaryoblastic leukemia, is highly expressed in differentiated muscle cells and promotes muscle differentiation by activating serum response factor (SRF). Here we show that Mkl1 expression is up-regulated during murine megakaryocytic differentiation and that enforced overexpression of MKL1 enhances megakaryocytic differentiation. When the human erythroleukemia (HEL) cell line is induced to dif  ...[more]

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