Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Gene expression in respiratory epithelial cells treated to induce StIR

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA110439 | ENA |

REPOSITORIES: ENA

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Publications


Pneumonia is a serious problem worldwide. We recently demonstrated that innate defense mechanisms of the lung are highly inducible against pneumococcal pneumonia. To determine the breadth of protection conferred by stimulation of lung mucosal innate immunity, and to identify cells and signaling pathways activated by this treatment, mice were treated with an aerosolized bacterial lysate, then challenged with lethal doses of bacterial and fungal pathogens. Mice were highly protected against a broa  ...[more]

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