Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Bead-based kinase phosphorylation profiling identifies SRC as a therapeutic target in glioblastoma

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA110577 | ENA |

REPOSITORIES: ENA

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Publications


The aberrant activation of tyrosine kinases represents an important oncogenic mechanism, and yet the majority of such events remain undiscovered. Here we describe a bead-based method for detecting phosphorylation of both wild-type and mutant tyrosine kinases in a multiplexed, high-throughput and low-cost manner. With the aim of establishing a tyrosine kinase-activation catalog, we used this method to profile 130 human cancer lines. Follow-up experiments on the finding that SRC is frequently phos  ...[more]

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