Dataset Information


Homo sapiens

ABSTRACT: UV- or oxidized lipid treated dermal skin fibroblasts

ORGANISM(S): Homo sapiens  



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NF-E2-related factor 2 regulates the stress response to UVA-1-oxidized phospholipids in skin cells.

Gruber Florian F   Mayer Herbert H   Lengauer Barbara B   Mlitz Veronika V   Sanders John M JM   Kadl Alexandra A   Bilban Martin M   de Martin Rainer R   Wagner Oswald O   Kensler Thomas W TW   Yamamoto Masayuki M   Leitinger Norbert N   Tschachler Erwin E  

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090831 1

Long-wavelength ultraviolet (UVA-1) radiation causes oxidative stress that modifies cellular molecules. To defend themselves against noxious oxidation products, skin cells produce detoxifying enzymes and antioxidants. We have recently shown that UVA-1 oxidized the abundant membrane phospholipid 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (PAPC), which then induced the stress-response protein heme oxygenase 1 (HO-1) in dermal fibroblasts. Here we examined the effects of UVA-1- and U  ...[more]

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