Dataset Information


Legionella pneumophila

ABSTRACT: Gene expression profiling of constitutively competent comR and proQ mutants and RNase R (rnr) mutant of L. pneumophila

ORGANISM(S): Legionella pneumophila  



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Loss of RNase R induces competence development in Legionella pneumophila.

Charpentier Xavier X   Faucher Sébastien P SP   Kalachikov Sergey S   Shuman Howard A HA  

Journal of bacteriology 20081010 24

RNase R is a processive 3'-5' exoribonuclease with a high degree of conservation in prokaryotes. Although some bacteria possess additional hydrolytic 3'-5' exoribonucleases such as RNase II, RNase R was found to be the only predicted one in the facultative intracellular pathogen Legionella pneumophila. This provided a unique opportunity to study the role of RNase R in the absence of an additional RNase with similar enzymatic activity. We investigated the role of RNase R in the biology of Legione  ...[more]

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