Dataset Information


Mus musculus

ABSTRACT: Novel Regulators of Fgf23 Expression and Mineralization in Hyp Bone

ORGANISM(S): Mus musculus  



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Novel regulators of Fgf23 expression and mineralization in Hyp bone.

Liu Shiguang S   Tang Wen W   Fang Jianwen J   Ren Jinyu J   Li Hua H   Xiao Zhousheng Z   Quarles L D LD  

Molecular endocrinology (Baltimore, Md.) 20090625 9

We used gene array analysis of cortical bone to identify Phex-dependent gene transcripts associated with abnormal Fgf23 production and mineralization in Hyp mice. We found evidence that elevation of Fgf23 expression in osteocytes is associated with increments in Fgf1, Fgf7, and Egr2 and decrements in Sost, an inhibitor in the Wnt-signaling pathway, were observed in Hyp bone. beta-Catenin levels were increased in Hyp cortical bone, and TOPflash luciferase reporter assay showed increased transcrip  ...[more]

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