Dataset Information


Homo sapiens

ABSTRACT: Analysis of ETS gene expression patterns uncovers novel ETS mediated gene silencing pathways in prostate cancers

ORGANISM(S): Homo sapiens  



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ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer.

Kunderfranco Paolo P   Mello-Grand Maurizia M   Cangemi Romina R   Pellini Stefania S   Mensah Afua A   Albertini Veronica V   Malek Anastasia A   Chiorino Giovanna G   Catapano Carlo V CV   Carbone Giuseppina M GM  

PloS one 20100510 5

ETS transcription factors regulate important signaling pathways involved in cell differentiation and development in many tissues and have emerged as important players in prostate cancer. However, the biological impact of ETS factors in prostate tumorigenesis is still debated.We performed an analysis of the ETS gene family using microarray data and real-time PCR in normal and tumor tissues along with functional studies in normal and cancer cell lines to understand the impact in prostate tumorigen  ...[more]

Publication: 1/3

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