Dataset Information


Mus musculus

ABSTRACT: Gender-specific gene repression of PPAR-alpha KO mice in liver and heart

ORGANISM(S): Mus musculus  



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Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice.

Leuenberger Nicolas N   Pradervand Sylvain S   Wahli Walter W  

The Journal of clinical investigation 20091001 10

As most metabolic studies are conducted in male animals, understanding the sex specificity of the underlying molecular pathways has been broadly neglected; for example, whether PPARs elicit sex-dependent responses has not been determined. Here we show that in mice, PPARalpha has broad female-dependent repressive actions on hepatic genes involved in steroid metabolism and immunity. In male mice, this effect was reproduced by the administration of a synthetic PPARalpha ligand. Using the steroid ox  ...[more]

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