Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Expression data from adipocytes and white adipose tissue of mice maintained on normal chow or high fat diet

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA111399 | ENA |

REPOSITORIES: ENA

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Publications


Increases in adiposity trigger metabolic and inflammatory changes that interfere with insulin action in peripheral tissues, culminating in beta cell failure and overt diabetes. We found that the cAMP Response Element Binding protein (CREB) is activated in adipose cells under obese conditions, where it promotes insulin resistance by triggering expression of the transcriptional repressor ATF3 and thereby downregulating expression of the adipokine hormone adiponectin as well as the insulin-sensitiv  ...[more]

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