Genomics

Dataset Information

118

Drosophila melanogaster


ABSTRACT: Characterization of expression changes in armi,rhino,aub,ago3 mutants by tiling array

ORGANISM(S): Drosophila melanogaster  

PROVIDER: PRJNA111411 | ENA |

REPOSITORIES: ENA

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Publications


Piwi-interacting RNAs (piRNAs) silence transposons in animal germ cells. piRNAs are thought to derive from long transcripts spanning transposon-rich genomic loci and to direct an autoamplification loop in which an antisense piRNA, bound to Aubergine or Piwi protein, triggers production of a sense piRNA bound to the PIWI protein Argonaute3 (Ago3). In turn, the new piRNA is envisioned to produce a second antisense piRNA. Here, we describe strong loss-of-function mutations in ago3, allowing a direc  ...[more]

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