Dataset Information


Mus musculus

ABSTRACT: Culture induced changes in Blood-Brain Barrier transcriptome: implications for amino acid transporters in vivo

ORGANISM(S): Mus musculus  



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Culture-induced changes in blood-brain barrier transcriptome: implications for amino-acid transporters in vivo.

Lyck Ruth R   Ruderisch Nadine N   Moll Anton G AG   Steiner Oliver O   Cohen Clemens D CD   Engelhardt Britta B   Makrides Victoria V   Verrey Francois F  

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090603 9

Tight homeostatic control of brain amino acids (AA) depends on transport by solute carrier family proteins expressed by the blood-brain barrier (BBB) microvascular endothelial cells (BMEC). To characterize the mouse BMEC transcriptome and probe culture-induced changes, microarray analyses of platelet endothelial cell adhesion molecule-1-positive (PECAM1(+)) endothelial cells (ppMBMECs) were compared with primary MBMECs (pMBMEC) cultured in the presence or absence of glial cells and with b.End5 e  ...[more]

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