Dataset Information


Homo sapiens

ABSTRACT: Human epithelial cell response to bacterial signal indole

ORGANISM(S): Homo sapiens  



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The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation.

Bansal Tarun T   Alaniz Robert C RC   Wood Thomas K TK   Jayaraman Arul A  

Proceedings of the National Academy of Sciences of the United States of America 20091204 1

Interkingdom signaling is established in the gastrointestinal tract in that human hormones trigger responses in bacteria; here, we show that the corollary is true, that a specific bacterial signal, indole, is recognized as a beneficial signal in intestinal epithelial cells. Our prior work has shown that indole, secreted by commensal Escherichia coli and detected in human feces, reduces pathogenic E. coli chemotaxis, motility, and attachment to epithelial cells. However, the effect of indole on i  ...[more]

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