Dataset Information


Streptococcus pneumoniae TIGR4

ABSTRACT: Role of Manganese Efflux for Signaling and Pathogenesis in Streptococcus pneumonia

ORGANISM(S): Streptococcus pneumoniae TIGR4  



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Role of the manganese efflux system mntE for signalling and pathogenesis in Streptococcus pneumoniae.

Rosch Jason W JW   Gao Geli G   Ridout Granger G   Wang Yong-Dong YD   Tuomanen Elaine I EI  

Molecular microbiology 20090217 1

The ability of bacteria to sense and respond to both environmental and intracellular metal concentrations plays an important role in pathogenesis. The acquisition of manganese is vital for the virulence of several bacterial species. Although manganese uptake systems have been well studied in bacteria, no manganese efflux system has yet been identified. In this study we have identified a cation diffusion facilitator (CDF) protein (Sp1552) of unknown substrate specificity that functions as a manga  ...[more]

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