Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Three non-invasive protein biomarkers for solid-organ transplant rejection found through integrative genomics

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA111441 | ENA |

REPOSITORIES: ENA

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Publications

Integrative urinary peptidomics in renal transplantation identifies biomarkers for acute rejection.

Ling Xuefeng B XB   Sigdel Tara K TK   Lau Kenneth K   Ying Lihua L   Lau Irwin I   Schilling James J   Sarwal Minnie M MM  

Journal of the American Society of Nephrology : JASN 20100211 4


Noninvasive methods to diagnose rejection of renal allografts are unavailable. Mass spectrometry followed by multiple-reaction monitoring provides a unique approach to identify disease-specific urine peptide biomarkers. Here, we performed urine peptidomic analysis of 70 unique samples from 50 renal transplant patients and 20 controls (n = 20), identifying a specific panel of 40 peptides for acute rejection (AR). Peptide sequencing revealed suggestive mechanisms of graft injury with roles for pro  ...[more]

Publication: 1/2

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