Dataset Information


Homo sapiens

ABSTRACT: Three non-invasive protein biomarkers for solid-organ transplant rejection found through integrative genomics

ORGANISM(S): Homo sapiens  



altmetric image


Integrative urinary peptidomics in renal transplantation identifies biomarkers for acute rejection.

Ling Xuefeng B XB   Sigdel Tara K TK   Lau Kenneth K   Ying Lihua L   Lau Irwin I   Schilling James J   Sarwal Minnie M MM  

Journal of the American Society of Nephrology : JASN 20100211 4

Noninvasive methods to diagnose rejection of renal allografts are unavailable. Mass spectrometry followed by multiple-reaction monitoring provides a unique approach to identify disease-specific urine peptide biomarkers. Here, we performed urine peptidomic analysis of 70 unique samples from 50 renal transplant patients and 20 controls (n = 20), identifying a specific panel of 40 peptides for acute rejection (AR). Peptide sequencing revealed suggestive mechanisms of graft injury with roles for pro  ...[more]

Publication: 1/2

Similar Datasets

| GSE33970 | GEO
| GSE88845 | GEO
| GSE119370 | GEO
| GSE88844 | GEO
2014-04-14 | E-GEOD-46122 | ArrayExpress
2015-07-13 | E-GEOD-46122 | ExpressionAtlas
2012-01-09 | E-GEOD-26625 | ArrayExpress
2014-03-01 | E-GEOD-15296 | ArrayExpress
| GSE15296 | GEO
2017-03-07 | E-MTAB-5136 | ArrayExpress