Dataset Information


Homo sapiens

ABSTRACT: Physiological defects associated with short hairpin RNA-mediated silencing of PGC-1-related coactivator (PRC)

ORGANISM(S): Homo sapiens  



altmetric image


Short hairpin RNA-mediated silencing of PRC (PGC-1-related coactivator) results in a severe respiratory chain deficiency associated with the proliferation of aberrant mitochondria.

Vercauteren Kristel K   Gleyzer Natalie N   Scarpulla Richard C RC  

The Journal of biological chemistry 20081126 4

PRC, a member of the PGC-1 coactivator family, is responsive to serum growth factors and up-regulated in proliferating cells. Here, we investigated its in vivo role by stably silencing PRC expression with two different short hairpin RNAs (shRNA1 and shRNA4) that were lentivirally introduced into U2OS cells. shRNA1 transductants exhibited nearly complete knockdown of PRC protein, whereas shRNA4 transductants expressed PRC protein at approximately 15% of the control level. Complete PRC silencing b  ...[more]

Similar Datasets

| GSE14428 | GEO
2013-12-05 | E-GEOD-52550 | ArrayExpress
| GSE107630 | GEO
2006-08-16 | GSE5538 | GEO
2015-07-29 | E-GEOD-52550 | ExpressionAtlas
2008-06-13 | E-GEOD-5538 | ArrayExpress
2014-07-24 | E-GEOD-49613 | ArrayExpress
2013-01-08 | E-GEOD-40439 | ArrayExpress
2009-04-23 | E-GEOD-6662 | ArrayExpress
2012-03-15 | GSE28206 | GEO