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Pathogenic Natural Antibodies Recognizing Annexin IV Are Required to Develop Intestinal Ischemia-Reperfusion Injury


ABSTRACT: Pathogenic Natural Antibodies Recognizing Annexin IV Are Required to Develop Intestinal Ischemia-Reperfusion Injury

PROVIDER: PRJNA112027 | ENA |

REPOSITORIES: ENA

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Pathogenic natural antibodies recognizing annexin IV are required to develop intestinal ischemia-reperfusion injury.

Kulik Liudmila L   Fleming Sherry D SD   Moratz Chantal C   Reuter Jason W JW   Novikov Aleksey A   Chen Kuan K   Andrews Kathy A KA   Markaryan Adam A   Quigg Richard J RJ   Silverman Gregg J GJ   Tsokos George C GC   Holers V Michael VM  

Journal of immunology (Baltimore, Md. : 1950) 20090501 9


Intestinal ischemia-reperfusion (IR) injury is initiated when natural IgM Abs recognize neo-epitopes that are revealed on ischemic cells. The target molecules and mechanisms whereby these neo-epitopes become accessible to recognition are not well understood. Proposing that isolated intestinal epithelial cells (IEC) may carry IR-related neo-epitopes, we used in vitro IEC binding assays to screen hybridomas created from B cells of unmanipulated wild-type C57BL/6 mice. We identified a novel IgM mAb  ...[more]

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