Dataset Information


Rattus norvegicus

ABSTRACT: Global gene expression changes in rat retinal ganglion cells after experimental glaucoma

ORGANISM(S): Rattus norvegicus  



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Global gene expression changes in rat retinal ganglion cells in experimental glaucoma.

Wang Dan Yi DY   Ray Arjun A   Rodgers Kathryn K   Ergorul Ceren C   Hyman Bradley T BT   Huang Wei W   Grosskreutz Cynthia L CL  

Investigative ophthalmology & visual science 20100324 8

Intraocular pressure (IOP) is an important risk factor in glaucoma. Gene expression changes were studied in glaucomatous rat retinal ganglion cells (RGCs) to elucidate altered transcriptional pathways.RGCs were back-labeled with Fluorogold. Unilateral IOP elevation was produced by injection of hypertonic saline into the episcleral veins. Laser capture microdissection (LCM) was used to capture an equal number of RGCs from normal and glaucomatous retinal sections. RNA was extracted and amplified,  ...[more]

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